Summary: In 2012, the University of Chicago and icddr,b were jointly awarded a paired planning grant under the first phase of the NIH GEOHealth program. The award was granted to build a network of researchers to tackle the health impacts of air and water pollution and climate change with local partner institutions, including government agencies (Atomic Energy Commission, Ministries of Health, Environment and Labor), academic institutions (NIPSOM, BRAC University, NICVD, and BSMMU), NGOs (URB, GIZ, and Phulki), and private sectors (BGMEA).

Summary: Globally, 200 million people including ~57 million in Bangladesh and ~17 million in the US, are chronically exposed to inorganic arsenic, and are at increased risk of the mortality, cancers, cardiovascular, pulmonary, and other non-malignant diseases. In collaboration with Columbia University, we established the Health Effects of Arsenic Longitudinal Study (HEALS)—a large, prospective cohort study based on individual-level data from a population exposed to a wide range of inorganic arsenic from drinking water in Araihazar, Bangladesh. Using a population-based sampling frame, we recruited 37,000 men and women (with >95% response rate) and collected detailed exposure and clinical data, as well as biological samples at baseline and biennially thereafter.

Summary: Arsenic has been reported to be a potent endocrine disruptor. Alterations in hormonal balance and gene deregulation in sensitive periods such as in in utero and early life may lead to clinical dysfunction or pathologies manifest in childhood and later life. The research has the following aims: (1) to evaluate whether in utero arsenic exposure and early childhood arsenic exposure are associated with thyroid and steroid hormones in children; (2) to evaluate whether in utero arsenic exposure and early childhood arsenic exposure are associated with gene expression profiles in children; and, (3) to longitudinally evaluate whether in utero arsenic exposure and early childhood arsenic exposure are associated with endocrine-related phenotypes in children.

Summary: Humans host more microbial cells than their own cells and the microbiome is increasingly considered to affect human health and wellbeing. Since bacterial profiles are modifiable, we are investigating the determinants and consequences of microbial variability in different body fluids. Specifically, we aim to evaluate whether; 1) the gut and oral microbiome may have significant impact on arsenic methylation capacity, and 2) the differences in gut and oral microbiome composition could contribute to population variation in susceptibility to cardiovascular and other health effects of arsenic exposure and other environmental exposures.

Summary: This study examines the effects of arsenic (As) exposure from drinking water on lung function and immune function in adults. We explored the possible protective role of vitamin D (vit. D) on lung function. The study was conducted among adults in the ongoing cohort in Araihazar, Bangladesh. Using the HEALS database, we have identified a total of 2,938 eligible participants for inclusion in the current study.

Summary: This study examines genetic and epigenetic factors related to arsenic and other environmental exposures as well as different clinical outcomes and their pre-clinical phenotypes in individuals in Araihazar, Bangladesh. The findings of this study will help us to identifying the gene-gene and gene-environment interactions that determine the onset of chronic disease, and afford us the opportunity to develop effective and sustainable disease prevention strategies for people in Bangladesh.

Summary: This study examines the neurocognitive and respiratory health effects of exposure to water arsenic and manganese (WAs and WMn, respectively) among adolescents in Araihazar, Bangladesh. Specifically, three questions are addressed. First, does the As-induced respiratory disease observed in adults also manifest itself in adolescents, and what are the possible physiologic mechanisms? Second, to what extent do associations between WAs and both lung and brain function reflects the effects of exposure in utero and infancy, periods of dramatic development for these systems? Third, are WAs and WMn associated with specific cognitive functions in addition to intelligence?

Summary: We initiated a pathology-based cancer registry in Bangladesh through a collaborative network of all histopathologists and cytopathologists, initially based in Dhaka city, followed by a nationwide network, with the ultimate target of establishing a regional and national-level population-based cancer registration system. For the last 4 years, we have collect data from different institutions including BSMMU, Dhaka Medical College, and Sir Salimullah Medical College hospitals. We are planning to expand our program throughout Dhaka.

Summary: The proposed study will examine the effects of biomass use on a number of novel markers of airway epithelial damage and inflammation related to cardiovascular and respiratory outcomes among adult females in Araihazar, Bangladesh. In this pilot study, we will recruit 120 non-smoking females who are exposed to water arsenic <5µg />L. The pilot study participants will be categorized into the following three groups (40 in each) depending on their biomass usage as follows: heavy biomass users, moderate biomass users, and non-biomass user subjects from households that do not use biomass for cooking.

Summary: We established the Bangladesh vitamin E and selenium Trial (BEST)—a 2×2 factorial randomized chemoprevention trial (RCT) for evaluating whether long-term vitamin E or selenium supplementation reduces the risk of non-melanoma skin cancer (NMSC) and diabetes mellitus in uniquely exposed 7,000 individuals. This study was designed to identify, recruit, and randomize 7,000 individuals with arsenic-related skin lesions into 4 treatment arms: vitamin E only (100 IU/day), L-selenomethionine only (200 µg/day), both vitamin E and selenium, and placebo.

Summary: The proposed study examines the joint effects of water arsenic (As) and Polycyclic Aromatic Hydrocarbons (PAH) from cigarettes smoke on lung function, inflammation and markers of immune function among adult males in Araihazar, Bangladesh. This study will add substantial new knowledge to the immunologic and pulmonary health effects of combined cigarette smoke (surrogate for PAH) and As exposures, which present a huge public health burden.

Summary: This project characterizes the impact of nutritional regulation of one-carbon metabolism on the inter-individual variability in As methylation. Glutathione (GSH), a key component of the primary antioxidant defense mechanism and the electron donor for As reduction, is synthesized from homocysteine, and this synthesis is regulated by intermediates of one-carbon metabolism.

1. Wu F, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Argos M, Levy D, Sarwar G, Ahsan H, Chen Y. Chen Y Betel quid use and mortality in Bangladesh: a cohort study. Bull World Health Organ 2015; 93(10):684-692.


2. Farzan SF, Karagas MR, Jiang J, Wu F, Liu M, Newman JD, Jasmine F, Kibriya MG, Paul-Brutus R, Parvez F, Argos M, Bryan MS, Eunus M, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, Graziano J, Ahsan H, Chen Y. Gene-arsenic interaction in longitudinal changes of blood pressure: Findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh.Toxicol Appl Pharmacol 2015; 288(1):95-105. doi: 10.1016/j.taap.2015.07.017.


3. Pesola GR, Argos M, Chen Y, Parvez F, Ahmed A, Hasan R, Rakibuz-Zaman M, Islam T, Eunus M, Sarwar G, Chinchilli VM, Neugut AI, Ahsan H. Dipstick proteinuria as a predictor of all-cause and cardiovascular disease mortality in Bangladesh: A prospective cohort study.Prev Med. 2015; 78:72-7. doi: 10.1016/j.ypmed.2015.07.009


4. Jiang J, Liu M, Parvez F, Wang B, Wu F, Eunus M, Bangalore S, Newman JD, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Slavkovich V, Argos M, Scannell Bryan M, Farzan SF, Hayes RB, Graziano JH, Ahsan H, Chen Y. Association between Arsenic Exposure from Drinking Water and Longitudinal Change in Blood Pressure among HEALS Cohort Participants.Environ Health Perspect 2015; 123(8):806-12.doi: 10.1289/ehp.1409004


5. Gao J, Tong L, Argos M, Scannell Bryan M, Ahmed A, Rakibuz-Zaman M, Kibriya MG, Jasmine F, Slavkovich V, Graziano JH, Ahsan H, Pierce BL.The Genetic Architecture of Arsenic Metabolism Efficiency: A SNP-Based Heritability Study of Bangladeshi Adults. Environ Health Perspect 2015 Oct; 123(10):985-92. doi: 10.1289/ehp.1408909


6. Seow WJ, Pan WC, Kile ML, Tong L, Baccarelli AA, Quamruzzaman Q, Rahman M, Mostofa G, Rakibuz-Zaman M, Kibriya M, Ahsan H, Lin X, Christiani DC. A distinct and replicable variant of the squamous cell carcinoma gene inositol polyphosphate-5-phosphatase modifies the susceptibility of arsenic-associated skin lesions in Bangladesh.Cancer 2015. doi: 10.1002/cncr.29291.


7. Aschebrook-Kilfoy B, Argos M, Pierce BL, Tong L, Jasmine F, Roy S, Parvez F, Ahmed A, Islam T, Kibriya MG, Ahsan H. Genome-wide association study of parity in Bangladeshi women.PLoS One 2015; 10(3):e0118488. doi: 10.1371/journal.pone.0118488


8. Jiang J, Liu M, Parvez F, Wang B, Wu F, Eunus M, Bangalore S, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Argos M, Scannell Bryan M, Graziano J, Hayes RB, Ahsan H, Chen Y. Association of major dietary patterns and blood pressure longitudinal change in Bangladesh. J Hypertens 2015; 33(6):1193-200. doi: 10.1097/HJH.0000000000000534.


9. Wu F, Jasmine F, Kibriya MG, Liu M, Cheng X, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Jiang J, Roy S, Paul-Brutus R, Slavkovich V, Islam T, Levy D, VanderWeele TJ, Pierce BL, Graziano JH, Ahsan H, Chen Y.Interaction between arsenic exposure from drinking water and genetic polymorphisms on cardiovascular disease in Bangladesh: a prospective case-cohort study.Environ Health Perspect 2015; 123(5):451-7. doi: 10.1289/ehp.1307883


10. Gao J, Roy S, Tong L, Argos M, Jasmine F, Rahaman R, Rakibuz-Zaman M, Parvez F, Ahmed A, Hore SK, Sarwar G, Slavkovich V, Yunus M, Rahman M, Baron JA, Graziano JH, Ahsan H, Pierce BL. Arsenic exposure, telomere length, and expression of telomere-related genes among Bangladeshi individuals. Environ Res 2015; 136:462-9. doi: 10.1016/j.envres.2014.09.040


11. Argos M, Chen L, Jasmine F, Tong L, Pierce BL, Roy S, Paul-Brutus R, Gamble MV, Harper KN, Parvez F, Rahman M, Rakibuz-Zaman M, Slavkovich V, Baron JA, Graziano JH, Kibriya MG, Ahsan H.Gene-specific differential DNA methylation and chronic arsenic exposure in an epigenome-wide association study of adults in Bangladesh. Environ Health Perspect 2015; 123(1):64-71. doi: 10.1289/ehp.1307884.

1. Scannell Bryan M, Argos M, Pierce B, Tong L, Rakibuz-Zaman M, Ahmed A, Rahman M, Islam T, Yunus M, Parvez F, Roy S, Jasmine F, Baron JA, Kibriya MG, Ahsan H. Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.PLoS One. 2014; 9(8):e105062. Doi: 10.1371/journal.pone.0105062.


2. Argos M, Parvez F, Rahman M, Rakibuz-Zaman M, Ahmed A, Hore SK, Islam T, Chen Y, Pierce BL, Slavkovich V, Olopade C, Yunus M, Baron JA, Graziano JH, Ahsan H. Arsenic and lung disease mortality in Bangladeshi adults. Epidemiology. 2014; 25(4):536-43. doi: 10.1097/EDE.0000000000000106.


3. Chen Y, Ge W, Parvez F, Bangalore S, Eunus M, Ahmed A, Islam T, Rakibuz-Zaman M, Hasan R, Argos M, Levy D, Sarwar G, Ahsan H. A prospective study of arm circumference and risk of death in Bangladesh.Int J Epidemiol 2014; 43(4):1187-96. doi: 10.1093/ije/dyu082.


4. Argos M, Tong L, Pierce BL, Rakibuz-Zaman M, Ahmed A, Islam T, Rahman M, Paul-Brutus R, Rahaman R, Roy S, Jasmine F, Kibriya MG, Ahsan H. Genome-wide association study of smoking behaviours among Bangladeshi adults.J Med Genet 2014; 51(5):327-33. doi: 10.1136/jmedgenet-2013-102151.


5. Wu F, Jasmine F, Kibriya MG, Liu M, Cheng X, Parvez F, Paul-Brutus R, Paul RR, Sarwar G, Ahmed A, Jiang J, Islam T, Slavkovich V, Rundek T, Demmer RT, Desvarieux M, Ahsan H, Chen Y.Interaction between arsenic exposure from drinking water and genetic susceptibility in carotid intima-media thickness in Bangladesh.Toxicol Appl Pharmacol 2014 1; 276(3):195-203. doi: 10.1016/j.taap.2014.02.014.


6. McClintock TR, Parvez F, Wu F, Wang W, Islam T, Ahmed A, Shaheen I, Sarwar G, Demmer RT, Desvarieux M, Ahsan H, Chen Y. Association between betel quid chewing and carotid intima-media thickness in rural Bangladesh.Int J Epidemiol 2014; 43(4):1174-82. doi: 10.1093/ije/dyu009.


7. McClintock TR, Chen Y, Parvez F, Makarov DV, Ge W, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, Bjurlin MA, Graziano JH, Ahsan H. Association between arsenic exposure from drinking water and hematuria: results from the Health Effects of Arsenic Longitudinal Study. Toxicol Appl Pharmacol 2014; 276(1):21-7. doi: 10.1016/j.taap.2014.01.015.

1. Pierce BL, Tong L, Argos M, Gao J, Farzana J, Roy S, Paul-Brutus R, Rahaman R, Rakibuz-Zaman M, Parvez F, Ahmed A, Quasem I, Hore SK, Alam S, Islam T, Harjes J, Sarwar G, Slavkovich V, Gamble MV, Chen Y, Yunus M, Rahman M, Baron JA, Graziano JH, Ahsan H. Arsenic metabolism efficiency has a causal role in arsenic toxicity: Mendelian randomization and gene-environment interaction. Int J Epidemiol 2013; 42(6):1862-71. doi: 10.1093/ije/dyt182.


2. van Geen A, Ahmed EB, Pitcher L, Mey JL, Ahsan H, Graziano JH, Ahmed KM. Comparison of two blanket surveys of arsenic in tube wells conducted 12 years apart in a 25 km(2) area of Bangladesh. Sci Total Environ. 2014 Aug 1; 488-489:484-92. doi:


3. Melkonian S, Argos M, Hall MN, Chen Y, Parvez F, Pierce B, Cao H, Aschebrook-Kilfoy B, Ahmed A, Islam T, Slavcovich V, Gamble M, Haris PI, Graziano JH, Ahsan H. Urinary and dietary analysis of 18,470 Bangladeshis reveal a correlation of rice consumption with arsenic exposure and toxicity.PLoS One. 2013; 8(11):e80691. doi: 10.1371/journal.pone.0080691.


4. Yinon L, Chen Y, Parvez F, Bangalore S, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Ahsan H. A prospective study of variability in systolic blood pressure and mortality in a rural Bangladeshi population cohort. Prev Med 2013; 57(6):807-12. doi: 10.1016/j.ypmed.2013.09.006.


5. Parvez F, Chen Y, Yunus M, Olopade C, Segers S, Slavkovich V, Argos M, Hasan R, Ahmed A, Islam T, Akter MM, Graziano JH, Ahsan H. Arsenic exposure and impaired lung function. Findings from a large population-based prospective cohort study. Am J Respir Crit Care Med 2013; 188(7):813-9. doi: 10.1164/rccm.201212-2282OC


6. George CM, Gamble M, Slavkovich V, Levy D, Ahmed A, Ahsan H, Graziano J. A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh.Environ Health. 2013; 12:52. doi: 10.1186/1476-069X-12-52.


7. Chen Y, Wu F, Graziano JH, Parvez F, Liu M, Paul RR, Shaheen I, Sarwar G, Ahmed A, Islam T, Slavkovich V, Rundek T, Demmer RT, Desvarieux M, Ahsan H. Arsenic exposure from drinking water, arsenic methylation capacity, and carotid intima-media thickness in Bangladesh.Am J Epidemiol 2013; 178(3):372-81. doi: 10.1093/aje/kwt001.


8. Chen Y, Wu F, Liu M, Parvez F, Slavkovich V, Eunus M, Ahmed A, Argos M, Islam T, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, Graziano J, Ahsan H. A prospective study of arsenic exposure, arsenic methylation capacity, and risk of cardiovascular disease in Bangladesh. Environ Health Perspect. 2013; 121(7):832-8. doi: 10.1289/ehp.1205797.


9. Argos M, Melkonian S, Parvez F, Rakibuz-Zaman M, Ahmed A, Chen Y, Ahsan H.A population-based prospective study of energy-providing nutrients in relation to all-cause cancer mortality and cancers of digestive organs mortality.Int J Cancer 2013; 133(10):2422-8. doi: 10.1002/ijc.28250.


10. Argos M, Rahman M, Parvez F, Dignam J, Islam T, Quasem I, K Hore S, T Haider A, Hossain Z, I Patwary T, Rakibuz-Zaman M, Sarwar G, La Porte P, Harjes J, Anton K, Kibriya MG, Jasmine F, Khan R, Kamal M, Shea CR, Yunus M, Baron JA, Ahsan H. Baseline comorbidities in a skin cancer prevention trial in Bangladesh. Eur J Clin Invest 2013; 43(6):579-88. doi: 10.1111/eci.12085.


11. Wu F, Chen Y, Parvez F, Segers S, Argos M, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Ahsan H. A prospective study of tobacco smoking and mortality in Bangladesh. PLoS One 2013; 8(3):e58516. doi: 10.1371/journal.pone.0058516.


12. Chen Y, Wu F, Parvez F, Ahmed A, Eunus M, McClintock TR, Patwary TI, Islam T, Ghosal AK, Islam S, Hasan R, Levy D, Sarwar G, Slavkovich V, van Geen A, Graziano JH, Ahsan H. Arsenic exposure from drinking water and QT-interval prolongation: results from the Health Effects of Arsenic Longitudinal Study. Environ Health Perspect 2013 Apr; 121(4):427-32. doi: 10.1289/ehp.1205197.


13. Syed EH, Melkonian S, Poudel KC, Yasuoka J, Otsuka K, Ahmed A, Islam T, Parvez F, Slavkovich V, Graziano JH, Ahsan H, Jimba M. Arsenic exposure and oral cavity lesions in Bangladesh.J Occup Environ Med 2013; 55(1):59-66. doi: 10.1097/JOM.0b013e31826bb686


14. Chen Y, McClintock TR, Segers S, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Ahsan H. Prospective investigation of major dietary patterns and risk of cardiovascular mortality in Bangladesh. Int J Cardiol 2013; 167(4):1495-501. doi: 10.1016/j.ijcard.2012.04.041

1. Syed EH, Poudel KC, Sakisaka K, Yasuoka J, Ahsan H, Jimba M. Quality of life and mental health status of arsenic-affected patients in a Bangladeshi population. J Health Popul Nutr 2012; 30(3):262-9.


2. Melkonian S, Argos M, Chen Y, Parvez F, Pierce B, Ahmed A, Islam T, Ahsan H. Intakes of several nutrients is associated with incidence of arsenic-related keratotic skin lesions in Bangladesh. J Nutr. 2012; 142(12):2128-34. doi: 10.3945/jn.112.165720


3. Argos M, Ahsan H, Graziano JH. Arsenic and human health: epidemiologic progress and public health implications.Rev Environ Health 2012; 27(4):191-5. doi: 10.1515/reveh-2012-0021.


4. Wu F, Jasmine F, Kibriya MG, Liu M, Wójcik O, Parvez F, Rahaman R, Roy S, Paul-Brutus R, Segers S, Slavkovich V, Islam T, Levy D, Mey JL, van Geen A, Graziano JH, Ahsan H, Chen Y. Association between arsenic exposure from drinking water and plasma levels of cardiovascular markers. Am J Epidemiol 2012; 175(12):1252-61. doi: 10.1093/aje/kwr464


5. Pierce BL, Kibriya MG, Tong L, Jasmine F, Argos M, Roy S, Paul-Brutus R, Rahaman R, Rakibuz-Zaman M, Parvez F, Ahmed A, Quasem I, Hore SK, Alam S, Islam T, Slavkovich V, Gamble MV, Yunus M, Rahman M, Baron JA, Graziano JH, Ahsan H. Genome-wide association study identifies chromosome 10q24.32 variants associated with arsenic metabolism and toxicity phenotypes in Bangladesh.PLoS Genet 2012; 8(2):e1002522. doi: 10.1371/journal.pgen.1002522.


6. Heck JE, Marcotte EL, Argos M, Parvez F, Ahmed A, Islam T, Sarwar G, Hasan R, Ahsan H, Chen Y. Betel quid chewing in rural Bangladesh: prevalence, predictors and relationship to blood pressure.. Int J Epidemiol 2012; 41(2):462-71. doi: 10.1093/ije/dyr191


7. Pesola GR1, Parvez F, Chen Y, Ahmed A, Hasan R, Ahsan H. Arsenic exposure from drinking water and dyspnoea risk in Araihazar, Bangladesh: a population-based study. Eur Respir J. 2012; 39(5):1076-83. doi: 10.1183/09031936.00042611

1. Parvez F, Wasserman GA, Factor-Litvak P, Liu X, Slavkovich V, Siddique AB, Sultana R, Sultana R, Islam T, Levy D, Mey JL, van Geen A, Khan K, Kline J, Ahsan H, Graziano JH. Arsenic exposure and motor function among children in Bangladesh.Environ Health Perspect 2011; 119(11):1665-70. doi: 10.1289/ehp.1103548.


2. Argos M, Kalra T, Pierce BL, Chen Y, Parvez F, Islam T, Ahmed A, Hasan R, Hasan K, Sarwar G, Levy D, Slavkovich V, Graziano JH, Rathouz PJ, Ahsan H. A prospective study of arsenic exposure from drinking water and incidence of skin lesions in Bangladesh. Am J Epidemiol 2011; 174(2):185-94. doi: 10.1093/aje/kwr062.


3. Chen Y, Graziano JH, Parvez F, Liu M, Slavkovich V, Kalra T, Argos M, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Levy D, van Geen A, Ahsan H. Arsenic exposure from drinking water and mortality from cardiovascular disease in Bangladesh: prospective cohort study.BMJ 2011; 342:d2431. doi: 10.1136/bmj.d2431.


4. Wasserman GA, Liu X, Parvez F, Factor-Litvak P, Ahsan H, Levy D, Kline J, van Geen A, Mey J, Slavkovich V, Siddique AB, Islam T, Graziano JH. Arsenic and manganese exposure and children's intellectual function. Neurotoxicology 2011; 32(4):450-7. doi: 10.1016/j.neuro.2011.03.009.


5. Louis ED, Hafeman D, Parvez F, Liu X, Alcalay RN, Islam T, Ahmed A, Siddique AB, Patwary TI, Melkonian S, Argos M, Levy D, Ahsan H. Tremor severity and age: a cross-sectional, population-based study of 2,524 young and midlife normal adults. Mov Disord 2011; 26(8):1515-20. doi: 10.1002/mds.23674.


6. Chen Y, Parvez F, Liu M, Pesola GR, Gamble MV, Slavkovich V, Islam T, Ahmed A, Hasan R, Graziano JH, Ahsan H. Association between arsenic exposure from drinking water and proteinuria: results from the Health Effects of Arsenic Longitudinal Study. Int J Epidemiol 2011; 40(3):828-35. doi: 10.1093/ije5/dyr022.


7. Louis ED, Hafeman D, Parvez F, Alcalay RN, Islam T, Siddique AB, Patwary TI, Melkonian S, Argos M, Levy D, Ahsan H. Prevalence of essential tremor in Araihazar, Bangladesh: a population-based study.Neuroepidemiology 2011; 36(2):71-6. doi: 10.1159/000323389.


8. Pilsner JR, Hall MN, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. Associations of plasma selenium with arsenic and genomic methylation of leukocyte DNA in Bangladesh. Environ Health Perspect 2011; 119(1):113-8. doi: 10.1289/ehp.1001937.


9. Pierce BL, Argos M, Chen Y, Melkonian S, Parvez F, Islam T, Ahmed A, Hasan R, Rathouz PJ, Ahsan H. Arsenic exposure, dietary patterns, and skin lesion risk in Bangladesh: a prospective study. Am J Epidemiol 2011; 173(3):345-54. doi: 10.1093/aje/kwq366.


10. Melkonian S, Argos M, Pierce BL, Chen Y, Islam T, Ahmed A, Syed EH, Parvez F, Graziano J, Rathouz PJ, Ahsan H. A prospective study of the synergistic effects of arsenic exposure and smoking, sun exposure, fertilizer use, and pesticide use on risk of premalignant skin lesions in Bangladeshi men.Am J Epidemiol 2011; 173(2):183-91. doi: 10.1093/aje/kwq357.


11. Ruiz de Luzuriaga AM, Ahsan H, Shea CR. Arsenical keratoses in Bangladesh--update and prevention strategies. Dermatol Clin 2011; 29(1):45-51. doi: 10.1016/j.det.2010.09.003.

1. Chen Y, Ahsan H, Slavkovich V, Peltier GL, Gluskin RT, Parvez F, Liu X, Graziano JH. No association between arsenic exposure from drinking water and diabetes mellitus: a cross-sectional study in Bangladesh.Environ Health Perspect 2010; 118(9):1299-305. doi: 10.1289/ehp.0901559


2. Heck JE, Nieves JW, Chen Y, Parvez F, Brandt-Rauf PW, Howe GR, Ahsan H. Protein and amino acid intakes in a rural area of Bangladesh. Food Nutr Bull 2010; 31(2):206-13.


3. Argos M, Kalra T, Rathouz PJ, Chen Y, Pierce B, Parvez F, Islam T, Ahmed A, Rakibuz-Zaman M, Hasan R, Sarwar G, Slavkovich V, van Geen A, Graziano J, Ahsan H. Arsenic exposure from drinking water, and all-cause and chronic-disease mortalities in Bangladesh (HEALS): a prospective cohort study. Lancet. 2010; 376(9737):252-8. doi: 10.1016/S0140-6736(10)60481-3.


4. Parvez F, Chen Y, Brandt-Rauf PW, Slavkovich V, Islam T, Ahmed A, Argos M, Hassan R, Yunus M, Haque SE, Balac O, Graziano JH, Ahsan H. A prospective study of respiratory symptoms associated with chronic arsenic exposure in Bangladesh: findings from the Health Effects of Arsenic Longitudinal Study (HEALS).Thorax 2010; 65(6):528-33. doi: 10.1136/thx.2009.119347.


5. Argos M, Rathouz PJ, Pierce BL, Kalra T, Parvez F, Slavkovich V, Ahmed A, Chen Y, Ahsan H. Dietary B vitamin intakes and urinary total arsenic concentration in the Health Effects of Arsenic Longitudinal Study (HEALS) cohort, Bangladesh.Eur J Nutr 2010; 49(8):473-81. doi: 10.1007/s00394-010-0106-y.


6. Pesola GR, Parvez F, Jasmin S, Hasan AK, Ahsan H. Dyspnea reproducibility in a rural Bangladesh population.Clin Respir J 2009; 3(4):222-8. doi: 10.1111/j.1752-699X.2009.00135.x.


7. Hall MN, Liu X, Slavkovich V, Ilievski V, Mi Z, Alam S, Factor-Litvak P, Ahsan H, Graziano JH, Gamble MV. Influence of cobalamin on arsenic metabolism in Bangladesh.Environ Health Perspect 2009; 117(11):1724-9. doi: 10.1289/ehp.0900734.


8. Pierce BL, Kalra T, Argos M, Parvez F, Chen Y, Islam T, Ahmed A, Hasan R, Rakibuz-Zaman M, Graziano J, Rathouz PJ, Ahsan H. A prospective study of body mass index and mortality in Bangladesh. Int J Epidemiol 2010; 39(4):1037-45. doi: 10.1093/ije/dyp364.

1. Chen Y, Parvez F, Gamble M, Islam T, Ahmed A, Argos M, Graziano JH, Ahsan H. Arsenic exposure at low-to-moderate levels and skin lesions, arsenic metabolism, neurological functions, and biomarkers for respiratory and cardiovascular diseases: review of recent findings from the Health Effects of Arsenic Longitudinal Study (HEALS) in Bangladesh. Toxicol Appl Pharmacol 2009; 239(2):184-92. doi: 10.1016/j.taap.2009.01.010.


2. Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. Folate deficiency, hyperhomocysteinemia, low urinary creatinine, and hypomethylation of leukocyte DNA are risk factors for arsenic-induced skin lesions.Environ Health Perspect 2009; 117(2):254-60. doi: 10.1289/ehp.11872.


3. Heck JE, Nieves JW, Chen Y, Parvez F, Brandt-Rauf PW, Graziano JH, Slavkovich V, Howe GR, Ahsan H. Dietary intake of methionine, cysteine, and protein and urinary arsenic excretion in Bangladesh. Environ Health Perspect 2009; 117(1):99-104. doi: 10.1289/ehp.11589.

1. Zablotska LB, Chen Y, Graziano JH, Parvez F, van Geen A, Howe GR, Ahsan H. Protective effects of B vitamins and antioxidants on the risk of arsenic-related skin lesions in Bangladesh. Environ Health Perspect 2008; 116(8):1056-62. doi: 10.1289/ehp.


2. Mahata J, Argos M, Verret W, Kibriya MG, Santella RM, Ahsan H. Effect of selenium and vitamin e supplementation on plasma protein carbonyl levels in patients with arsenic-related skin lesions.Nutr Cancer 2008; 60(1):55-60. doi: 10.1080/01635580701761282.


3. Parvez F, Chen Y, Brandt-Rauf PW, Bernard A, Dumont X, Slavkovich V, Argos M, D'Armiento J, Foronjy R, Hasan MR, Eunus HE, Graziano JH, Ahsan H. Nonmalignant respiratory effects of chronic arsenic exposure from drinking water among never-smokers in Bangladesh.Environ Health Perspect 2008; 116(2):190-5. doi: 10.1289/ehp.9507.


4. Heck JE, Chen Y, Grann VR, Slavkovich V, Parvez F, Ahsan H. Arsenic exposure and anemia in Bangladesh: a population-based study.J Occup Environ Med 2008; 50(1):80-7. doi: 10.1097/JOM.0b013e31815ae9d4.

1. Chen Y, Santella RM, Kibriya MG, Wang Q, Kappil M, Verret WJ, Graziano JH, Ahsan H. Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules. Environ Health Perspect 2007; 115(10):1415-20.


2. Gamble MV, Liu X, Slavkovich V, Pilsner JR, Ilievski V, Factor-Litvak P, Levy D, Alam S, Islam M, Parvez F, Ahsan H, Graziano JH. Folic acid supplementation lowers blood arsenic.Am J Clin Nutr 2007; 86(4):1202-9.


3. Pilsner JR, Liu X, Ahsan H, Ilievski V, Slavkovich V, Levy D, Factor-Litvak P, Graziano JH, Gamble MV. Genomic methylation of peripheral blood leukocyte DNA: influences of arsenic and folate in Bangladeshi adults. Am J Clin Nutr 2007; 86(4):1179-86.


4. Hafeman D, Factor-Litvak P, Cheng Z, van Geen A, Ahsan H. Association between manganese exposure through drinking water and infant mortality in Bangladesh. Environ Health Perspect 2007; 115(7):1107-12.


5. Chen Y, van Geen A, Graziano JH, Pfaff A, Madajewicz M, Parvez F, Hussain AZ, Slavkovich V, Islam T, Ahsan H. Reduction in urinary arsenic levels in response to arsenic mitigation efforts in Araihazar, Bangladesh.Environ Health Perspect 2007; 115(6):917-23.


6. Ahsan H, Chen Y, Kibriya MG, Slavkovich V, Parvez F, Jasmine F, Gamble MV, Graziano JH. Arsenic metabolism, genetic susceptibility, and risk of premalignant skin lesions in Bangladesh. Cancer Epidemiol Biomarkers Prev 2007; 16(6):1270-8.


7. Heck JE, Gamble MV, Chen Y, Graziano JH, Slavkovich V, Parvez F, Baron JA, Howe GR, Ahsan H. Consumption of folate-related nutrients and metabolism of arsenic in Bangladesh.Am J Clin Nutr 2007; 85(5):1367-74.


8. Argos M, Parvez F, Chen Y, Hussain AZ, Momotaj H, Howe GR, Graziano JH, Ahsan H. Socioeconomic status and risk for arsenic-related skin lesions in Bangladesh.Am J Public Health 2007; 97(5):825-31.


9. Wasserman GA, Liu X, Parvez F, Ahsan H, Factor-Litvak P, Kline J, van Geen A, Slavkovich V, Loiacono NJ, Levy D, Cheng Z, Graziano JH. Water arsenic exposure and intellectual function in 6-year-old children in Araihazar, Bangladesh. Environ Health Perspect 2007; 115(2):285-9.


10. Chen Y, Hall M, Graziano JH, Slavkovich V, van Geen A, Parvez F, Ahsan H. A prospective study of blood selenium levels and the risk of arsenic-related premalignant skin lesions. Cancer Epidemiol Biomarkers Prev 2007; 16(2):207-13.


11. Kibriya MG, Jasmine F, Argos M, Verret WJ, Rakibuz-Zaman M, Ahmed A, Parvez F, Ahsan H. Changes in gene expression profiles in response to selenium supplementation among individuals with arsenic-induced pre-malignant skin lesions. Toxicol Lett 2007; 169(2):162-76.

1. Chen Y, Hakim ME, Parvez F, Islam T, Rahman AM, Ahsan H. Arsenic exposure from drinking-water and carotid artery intima-medial thickness in healthy young adults in Bangladesh. J Health Popul Nutr 2006; 24(2):253-7.


2. Chen Y, Factor-Litvak P, Howe GR, Graziano JH, Brandt-Rauf P, Parvez F, van Geen A, Ahsan H. Arsenic exposure from drinking water, dietary intakes of B vitamins and folate, and risk of high blood pressure in Bangladesh: a population-based, cross-sectional study.Am J Epidemiol 2007; 165(5):541-52.


3. Chen Y, Factor-Litvak P, Howe GR, Parvez F, Ahsan H. Nutritional influence on risk of high blood pressure in Bangladesh: a population-based cross-sectional study. Am J Clin Nutr 2006; 84(5):1224-32.


4. Gamble MV, Liu X, Ahsan H, Pilsner JR, Ilievski V, Slavkovich V, Parvez F, Chen Y, Levy D, Factor-Litvak P, Graziano JH. Folate and arsenic metabolism: a double-blind, placebo-controlled folic acid-supplementation trial in Bangladesh.Am J Clin Nutr 2006; 84(5):1093-101.


5. Hall M, Chen Y, Ahsan H, Slavkovich V, van Geen A, Parvez F, Graziano J. Blood arsenic as a biomarker of arsenic exposure: results from a prospective study.Toxicology 2006; 225(2-3):225-33.


6. Argos M, Kibriya MG, Parvez F, Jasmine F, Rakibuz-Zaman M, Ahsan H. Gene expression profiles in peripheral lymphocytes by arsenic exposure and skin lesion status in a Bangladeshi population.Cancer Epidemiol Biomarkers Prev 2006; 15(7):1367-75.


7. Chen Y, Graziano JH, Parvez F, Hussain I, Momotaj H, van Geen A, Howe GR, Ahsan H. Modification of risk of arsenic-induced skin lesions by sunlight exposure, smoking, and occupational exposures in Bangladesh.Epidemiology 2006; 17(4):459-67.


8. Ahsan H, Chen Y, Parvez F, Zablotska L, Argos M, Hussain I, Momotaj H, Levy D, Cheng Z, Slavkovich V, van Geen A, Howe GR, Graziano JH. Arsenic exposure from drinking water and risk of premalignant skin lesions in Bangladesh: baseline results from the Health Effects of Arsenic Longitudinal Study. Am J Epidemiol 2006; 163(12):1138-48.


9. Parvez F, Chen Y, Argos M, Hussain AZ, Momotaj H, Dhar R, van Geen A, Graziano JH, Ahsan H. Prevalence of arsenic exposure from drinking water and awareness of its health risks in a Bangladeshi population: results from a large population-based study.Environ Health Perspect 2006; 114(3):355-9.


10. Wasserman GA, Liu X, Parvez F, Ahsan H, Levy D, Factor-Litvak P, Kline J, van Geen A, Slavkovich V, LoIacono NJ, Cheng Z, Zheng Y, Graziano JH. Water manganese exposure and children's intellectual function in Araihazar, Bangladesh.Environ Health Perspect 2006; 114(1):124-9.


11. Hafeman D, Ahsan H, Islam T, Louis E. Betel quid: Its tremor-producing effects in residents of Araihazar, Bangladesh. Mov Disord 2006; 21(4):567-71.

1. Gamble MV, Liu X, Ahsan H, Pilsner R, Ilievski V, Slavkovich V, Parvez F, Levy D, Factor-Litvak P, Graziano JH. Folate, homocysteine, and arsenic metabolism in arsenic-exposed individuals in Bangladesh. Environ Health Perspect 2005; 113(12):1683-8.


2. Verret WJ, Chen Y, Ahmed A, Islam T, Parvez F, Kibriya MG, Graziano JH, Ahsan H. A randomized, double-blind placebo-controlled trial evaluating the effects of vitamin E and selenium on arsenic-induced skin lesions in Bangladesh. J Occup Environ Med 2005; 47(10):1026-35.


3. Ahsan H, Chen Y, Parvez F, Argos M, Hussain AI, Momotaj H, Levy D, van Geen A, Howe G, Graziano J. Health Effects of Arsenic Longitudinal Study (HEALS): description of a multidisciplinary epidemiologic investigation.J Expo Sci Environ Epidemiol 2006; 16(2):191-205.


4. Hafeman DM, Ahsan H, Louis ED, Siddique AB, Slavkovich V, Cheng Z, van Geen A, Graziano JH. Association between arsenic exposure and a measure of subclinical sensory neuropathy in Bangladesh. J Occup Environ Med. 2005; 47(8):778-84.


5. Gamble MV, Ahsan H, Liu X, Factor-Litvak P, Ilievski V, Slavkovich V, Parvez F, Graziano JH. Folate and cobalamin deficiencies and hyperhomocysteinemia in Bangladesh. Am J Clin Nutr 2005; 81(6):1372-7.

1. Chen Y, Ahsan H, Parvez F, Howe GR. Validity of a food-frequency questionnaire for a large prospective cohort study in Bangladesh. Br J Nutr 2004; 92(5):851-9.

1. Van Geen A, Ahsan H, Horneman AH, Dhar RK, Zheng Y, Hussain I, Ahmed KM, Gelman A, Stute M, Simpson HJ, Wallace S, Small C, Parvez F, Slavkovich V, Loiacono NJ, Becker M, Cheng Z, Momotaj H, Shahnewaz M, Seddique AA, Graziano JH. Promotion of well-switching to mitigate the current arsenic crisis in Bangladesh.Bull World Health Organ 2002; 80(9):732-7.